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KMID : 0858520100140010031
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Journal of the Korean Society of Magnetic Resonance in Medicine
2010 Volume.14 No. 1 p.31 ~ p.40
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Ferucarbotran-Enhanced Hepatic MRI at 3T Unit: Quantitative and Qualitative Comparison of Fast Breath-hold Imaging Sequences
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Cho Kyung-Eun
Yu Jeong-Sik
Chung Jae-Joon
Kim Joo-Hee
Kim Ki-Whang
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Abstract
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Purpose: To compare the relative values of various fast breath-hold imaging sequences for superparamagnetic iron-oxide (SPIO)-enhanced hepatic MRI for the assessment of solid focal lesions with a 3T MRI unit.
Materials and Methods : 102 consecutive patients with one or more solid malignant hepatic lesions were evaluated by spoiled gradient echo (GRE) sequences with three different echo times (2.4 msec [GRE_2.4], 5.8 msec [GRE_5.8], and 10 msec [GRE_10]) for -weighted imaging in addition to T2-weighted turbo spin echo (TSE) sequence following intravenous SPIO injection. Image qualities of the hepatic contour, vascular landmarks and artifacts were rated by two independent readers using a four-point scale. For quantitative analysis, contrast-to-noise ratio (CNR) was measured in 170 solid focal lesions larger than 1 cm (107 hepatocellular carcinomas, nine cholangiocarcinomas and 54 metastases).
Results: GRE_5.8 showed the highest mean points for hepatic contour, vascular anatomy and imaging artifact presence among all of the subjected sequences (p<0.001) and was comparable (p=0.414) with GRE_10 with regard to lesion conspicuity. The mean CNRs were significantly higher (p<0.001) in the following order: GRE_10 (), GRE_5.8 (), TSE (), and GRE_2.4 (). The mean CNRs of CCCs and metastases were higher than those of HCCs for all imaging sequences (p<0.05).
Conclusion: Regarding overall performances, GRE using a moderate echo time of 5.8 msec can provide the most reliable data among the various fast breath-hold SPIO-enhanced hepatic MRI sequences at 3T unit despite the lower CNR of GRE_5.8 compared to that of GRE_10.
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KEYWORD
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Liver neoplasm, Magnetic resonance (MR), Superparamagnetic iron oxide (SPIO)
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